Query   'FAT domain'  matched   5 Records

Record No : 1

Instance ID11160
Regular Expression[LV][DE][^P][LM][LM][^P][^P]L[^P]
Motif InstanceLDRLMASLS
Bait Uniprot AccessionO43294
Bait Uniprot IdentifierTGFI1_HUMAN
Bait Gene NameTGFB1I1
Bait OrganismHomo sapiens (Human)
Sequence Position158-166
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Co-IP; Mutation analysis
Interaction ID21160
Interacting DomainFAT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11463817
CommentsHuman Hydrogen peroxide-inducible clone 5 (Hic-5) protein interacts with human Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif

Record No : 2

Instance ID11161
Regular Expression[LV][DE][^P][LM][LM][^P][^P]L[^P]
Motif InstanceLDRLLLELN
Bait Uniprot AccessionP49024
Bait Uniprot IdentifierPAXI_CHICK
Bait Gene NamePXN
Bait OrganismGallus gallus (Chicken)
Sequence Position145-153
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)NMR
Interaction ID21161
Interacting DomainFAT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11909967
CommentsChicken Paxillin (PXN) interacts with Chicken Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif

Record No : 3

Instance ID11162
Regular Expression[LV][DE][^P][LM][LM][^P][^P]L[^P]
Motif InstanceLDELMASLS
Bait Uniprot AccessionP49023
Bait Uniprot IdentifierPAXI_HUMAN
Bait Gene NamePXN
Bait OrganismHomo sapiens (Human)
Sequence Position266-274
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography
Interaction ID21162
Interacting DomainFAT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14527389
CommentsHuman Paxillin (PXN) interacts with human Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif (266-274)

Record No : 4

Instance ID11163
Regular Expression[LV][DE][^P][LM][LM][^P][^P]L[^P]
Motif InstanceLDELMASLS
Bait Uniprot AccessionP49023
Bait Uniprot IdentifierPAXI_HUMAN
Bait Gene NamePXN
Bait OrganismHomo sapiens (Human)
Sequence Position266-274
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography
Interaction ID21163
Interacting DomainFAT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19358827
CommentsHuman Paxillin (PXN) interacts with human Protein tyrosine kinase 2 beta (PTK2B)/ Focal adhesion kinase 2 (FAK2) through its LD motif

Record No : 5

Instance ID11164
Regular Expression[LV][DE][^P][LM][LM][^P][^P]L[^P]
Motif InstanceLDALLADLE
Bait Uniprot AccessionP49023
Bait Uniprot IdentifierPAXI_HUMAN
Bait Gene NamePXN
Bait OrganismHomo sapiens (Human)
Sequence Position4-12
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Co-IP; Peptide binding to perpetrator; Pull down(His tag); Pull down(GST tag); Competition binding; Mutation analysis; Colocalization
Interaction ID21164
Interacting DomainFAT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20489202, 11304546, 10330411, 11134073
CommentsHuman Paxillin (PXN) interacts with human Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif (4-12)


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)